This includes NAC, any combination suppliment with NAC or reduced glutathione, and direct glutathione in the forms of injection, oral, transdermal, you name it, the reaction is the same, and ive tried them all. Something i've noticed with every method of raising glutathione (except methylation), is a strong detox/herx reaction. I have realised that raising it is something I need to do more than anything else IMO, as my CFS/FM/MCS is VERY much based on poor liver function, and concurrent poor general body detox ability. Mine was extremely low, almost non existent compared to normal! That was also during the 2nd year of my CFS, which is now in the 10th year.
I've been one of these as proved by my test with ARL (smokies) by functional liver detox profile. As many of us know, most ppl with CFS have low glutathione.
